Teratogenic drugs and their effects
Alcohol in pregnancy -- Fetal Alcohol Syndrome (FAH) - Midfacial hypoplasia and Long philtrum
Using DES in pregnancy - New born with T shaped Uterus
Dilantin/Phenytoin -- Craniofacial dysmorphism (5-10%) and also nail hypoplasia
Isotretinoin (Accutane) - Microtia -small ear - severe birth defects also heart problem
Lithium - Ebstein anomaly - large Right arium
Tetracyclin - Deciduous teeth discoloration (after 4 month)
Thalidomide - Phocomelia (Limb reduction defects exposure from Day 42-48)
Valproic Acid (Depakote) - Neural Tube Defects like Spina bifida , Congenital Heart disease
Coumadin - Chondrodysplasia punctata also optic atrophy
