Alcohol in pregnancy -- Fetal Alcohol Syndrome (FAH) - Midfacial hypoplasia and Long philtrum Using DES in pregnancy - New born with T shaped Uterus Dilantin/Phenytoin -- Craniofacial dysmorphism (5-10%) and also nail hypoplasia Isotretinoin (Accutane) - Microtia -small ear - severe birth defects also heart problem Lithium - Ebstein anomaly - large Right arium Tetracyclin - Deciduous teeth discoloration (after 4 month) Thalidomide - Phocomelia (Limb reduction defects exposure from Day 42-48) Valproic Acid (Depakote) - Neural Tube Defects like Spina bifida , Congenital Heart disease Coumadin - Chondrodysplasia punctata also optic atrophy