Allergic Interstitial Nephritis
Etiology :
70 % of cases due to adverse effect to medications
Drugs
1.Penicillins
2.Cephalosporins
3.Sulfa drugs
4.Allopurinol
5.Rifampin
6.Quinolones.
it happens from the first dose.As compared to Aminoglycosides take 5-10 days.
Infections (viruses,bacteria or fungi).Most common causes includes
1.Leptospirosis
2.Legionella
3.CMV
4.Rickettsia
5.Streptococci
Autoimmune disease
1.SLE
2.Sjogren syndrome
3.Sarcoidosis
4.Cryoglobulinemia
Dx:
1.Rash
2.Fever
3.Joint pain
4.Eosinophilia
5.Increased serum IgE
Best initial test-urinalysis
1.Eosinophiluria (Wright or Giemsa stain)
2.Hematuria
3.Proteinuria (<2g hrs="" p="">
Most accurate test
1.Biopsy
2.Rarely performed
Rx
1.Stop the offending agent
2.+/- corticosteroids
Etiology :
70 % of cases due to adverse effect to medications
Drugs
1.Penicillins
2.Cephalosporins
3.Sulfa drugs
4.Allopurinol
5.Rifampin
6.Quinolones.
it happens from the first dose.As compared to Aminoglycosides take 5-10 days.
Infections (viruses,bacteria or fungi).Most common causes includes
1.Leptospirosis
2.Legionella
3.CMV
4.Rickettsia
5.Streptococci
Autoimmune disease
1.SLE
2.Sjogren syndrome
3.Sarcoidosis
4.Cryoglobulinemia
Dx:
1.Rash
2.Fever
3.Joint pain
4.Eosinophilia
5.Increased serum IgE
Best initial test-urinalysis
1.Eosinophiluria (Wright or Giemsa stain)
2.Hematuria
3.Proteinuria (<2g hrs="" p="">
Most accurate test
1.Biopsy
2.Rarely performed
Rx
1.Stop the offending agent
2.+/- corticosteroids
No comments:
Post a Comment