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Influenza.

Cause of massive periodic epidemic and pandemic

RNA virus, bound by a nucleoprotein that determines the virus type (A, B, or C)

lipid bilayer containing the viral hemagglutinin and neuraminidase, which determine the subtype (e.g., H1N1, H3N2, etc

antigenic drift
antigenic shift
bird flu: H5N1
Vaccines available, and advised especially in elderly.

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