Disorders Associated with Splenomegaly.

I. Infections

Nonspecific splenitis of various blood-borne infections (particularly infective endocarditis)

Infectious mononucleosis

Tuberculosis

Typhoid fever

Brucellosis

Cytomegalovirus

Syphilis

Malaria

Histoplasmosis

Toxoplasmosis

Kala-azar

Trypanosomiasis

Schistosomiasis

Leishmaniasis

Echinococcosis

II. Congestive States Related to Portal Hypertension

Cirrhosis of the liver

Portal or splenic vein thrombosis

Cardiac failure

III. Lymphohematogenous Disorders

Hodgkin lymphoma

Non-Hodgkin lymphomas and lymphocytic leukemias

Multiple myeloma

Myeloproliferative disorders

Hemolytic anemias

Thromobocytopenic purpura

IV. Immunologic-Inflammatory Conditions

Rheumatoid arthritis

Systemic lupus erythematosus

V. Storage Diseases

Gaucher disease

Niemann-Pick disease

Mucopolysaccharidoses

VI. Miscellaneous

Amyloidosis

Primary neoplasms and cysts

Secondary neoplasm and metastasis.