DIFFUSE LARGE B CELL LYMPHOMA.

It is an aggressive tumor – constitutes 60 to 70% of all aggressive lymphoid neoplasms

Characteristics

Large cell size of neoplastic B cells

Diffuse pattern of growth

Subtypes

1. Immunodeficiency associated LBCL

Occurs in End stage HIV infection

SCID

Allogenic BMT

Solid organ transplantation

The neoplastic B cells are often latently infected with EBV

2. Body cavity LBCL

Arises as malignant pleural or ascitic effusions

Occurs in advanced HIV & Elderly people

The neoplastic B cells are infected with HHV-8

Patients typically presents with a RAPIDLY ENLARGING MASS at a SINGLE NODAL or EXTRANODAL SITE (GIT, Skin, Brain or Bone)

The cells are large, with prominent nucleoli and abundant cytoplasm